Born in Padula in southern Italy, Brigante moved to Los Angeles in 1897. There he found work as a sign painter and studied landscape painting with Hanson Puthoff, Rex Slinkard and Val Costello. During WWI, he served in the army and afterwards he studied with Stanton McDonald-Wright.
Brigante's first exhibition took place at the Los Angeles County Museum of Art in 1921 and from 1923-1924 he studied in New York City where he held a show at the Brooklyn Museum. He returned to Los Angeles and became a member of the California Watercolor Society. During the 1940s and 1950s he experimented with automatic drawing and after 1975, he created a series of acrylic panels.