A child prodigy, Bianco held her first exhibition at the age of twelve at the Leicester Galleries in London, which brought her to international recognition. Soon after this show, Walter de la Mare wrote a series of poems to accompany some of her drawings. Arranged by Mitchell Kennedy, her first American exhibition took place at the Anderson Galleries in 1922.
On the strength of her newfound American success , Bianco moved to New York with her parents and printed her first lithographs in 1922 with printmaker, George Miller. She participated extensively in exhibitions in several U.S. cities, including Los Angeles and San Francisco in 1922, Boston and Chicago in 1923 and New York in 1924, 1928 and 1937. She was awarded the Guggenheim Fellowship in 1930, which enabled her to spend a year in Florence and Rome where she wrote "Starlit Journey".