Notably an abstract painter, Boothe is also highly respected for his accomplishments in various art forms and for his work as an educator. He received a B.A. from Colorado College before moving to New York in 1967 to participate in the Whitney Museum Independant Study Program, learning critical theory and studio art. He was awarded an honorary Doctorate of Arts degree from Colorado College in 1989 in recognition of his mid-career accomplishments and has furthured his education by taking part in postgraduate programs, which include the University of California at Berkeley philosophy department, the Harvard Center for Renaissance Studies in Italy and the American School for Classical Studies in Athens.
Boothe was awarded an NEA Artist Fellowship in 1975 and a Guggenheim Fellowship for painting in 1985. He was an Associate Professor at Princeton University from 1988-1994, an Adjunct Instructor at the School of Visual Arts from 1979-1988 and he is currently the Director of the School of Art at the University of Ohio in Athens.