Friedeberg and his parents immigrated to Mexico in 1940. Having shown an early inclination for drawing and reading, he studied architecture at the Universidad Iberoamericana, where he was profoundly influenced by the teaching of Mathias Goeritz. At the age of twenty-two, Friedeberg had his first solo exhibition in 1959.
Although his artworks, filled to overflowing with surprise, are sometimes described as examples of Surrealism or fantastic realism, they are not easily definable in terms of conventional categories. His works include paintings, sculpture, printmaking, installations, and constructed montages; where the surrealist space is populated with borrowed and personal symbols, from classical images to Disney figures.
He has held individual shows in Mexico, the United States, and Europe, and participated in group shows in Berlin and in the 1969 Biennial de Sao Paulo.